Mesoglycan, a natural preparation of glycosaminoglycans (GAGs), is a polysaccharide complex, rich in sulphur radicals with a strong negative electrical charge. It is extracted from pig intestines and is composed of heparin-like polysaccharides, dermatan sulphate and small and variable amounts of chondroitin sulphate. Vascular glycosaminoglycans (GAGs) are essential components of the endothelium and vascular wall and have been shown to be involved in several biological functions.
The pharmacological activity of mesoglycan is due to its antiatherogenic (inhibition of platelet adhesion, stimulation of the enzyme lipoprotein lipase, inhibition of the proliferation of tunica media smooth muscle cells), antithrombotic (activation of antithrombin III and heparin cofactor II) and profibrinolytic (stimulation of tissue plasminogen activator) effects. Mesoglycan is able to restore the selective physiological barrier properties expressed by the capillary endothelia, thus exerting effective anti-oedematous activity.
- Prophylaxis and treatment of vascular diseases that can lead to varicose veins and other conditions (venous insufficiency)
- Leg sores caused by weak blood circulation (chronic venous ulcers)